منابع مشابه
Metabolism of Neoplastic Tissue
sis, an outstanding characteristic of neoplastic cells, remains unexplained. This phenomenon has been variously attributed to disturbances of res piration, to deficiencies of electron transport en zymes or co-factors, and to a lack of the citric acid cycle (2, 4, 14, 23). However, none of these hy potheses has decisive experimental support, and against them can be cited the observations that tu...
متن کاملMetabolism of neoplastic tissue. III. Diphosphopyridine nucleotide requirements for oxidations by mitochondria of neoplastic and non-neoplastic tissues.
In previous publications we reported that oxidative processes of the citric acid cycle in tumor homogenates (29) or mitochondria isolated there from (30) are limited by the loss of diphosphopyridine nucleotide activity and that oxygen consump tion can be restored by the addition of this coenzyme to the medium in relatively high concen tration. The present report represents a further study of th...
متن کاملMetabolism of neoplastic tissue. V. Fatty acid oxidation in slices of transplanted tumors.
A number of reports have appeared in recent years which indicate that fatty acids may not be metabolized by neoplastic cells (1,3,5,10), but, in general, little attention has been given to this problem. When recent studies with isotopie tracers (8, 15, 16) demonstrated that tumor slices in vitro can oxidize a variety of carbohydrate intermedi ates and fatty acids, a study of fatty acid oxida ti...
متن کاملMetabolism of neoplastic tissue. I. The oxidation of carbohydrate and fatty acids in transplanted tumors.
ary metabolism of neoplastic tissues the present investigation was undertaken to obtain informa tion concerning the carbon sources and the path ways of respiration in a series of transplanted tumors of the mouse and rat. Ever since the dis closure, by Warburg, of the high aerobic glycoly sis of tumors (21), the general conception has pre vailed that neoplastic tissue is characterized by a distu...
متن کاملHuman Neoplastic Cells in Tissue
The establishment and cultivation o ľ two human neoplastic cell lines is described. The cell line B-5GT was derived from bono giant cell tumor and B-6F8 from poorly differentiated fibrosarcoma. In comparison to the normal skin fibroblasts both cell lines have a potential for "indefinite" multiplication in vitro and 1 hoy exhibit growth properties which are asso ciated with malignant transforma...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1956
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)50804-3